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5 Clinical therapeutic approaches in MASH and T2DM The management of metabolic dysfunction-associated steatohepatitis (MASH) complicated by type 2 diabetes mellitus (T2DM) requires multi-pathway therapeutic strategies due to the systemic and interconnected nature of these conditions (121)

Fat droplet formation decreased, and the cells accumulated less fat even when exposed to conditions that normally promote fat storage

Concurrent use is mechanistically redundant and amplifies negative feedback suppression

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Conversely, those with diarrhoea should ensure adequate fluid and electrolyte replacement to prevent dehydration