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Cycle Duration and Monitoring Typical cycle: 1224 weeks Monitoring: baseline and 1012 week IGF-1 measurement is the most common biomarker Washout: 48 weeks between cycles is standard practitioner practice Contraindications Active malignancy GH/IGF-1 axis elevation is a theoretical oncogenic concern Diabetes mellitus GH elevates insulin resistance

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P., Kean, J., Sarris, J., Neale, C., Scholey, A