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For Older Adults: Studies show that slightly higher protein intakes of 1.2 to 1.76 grams of protein per pound of body weight (0.55 to 0.80 g/lb) per day helped older folks and seniors maintain muscle into their 70s
Researchers should also consider the contraindications for semaglutide, including: History of thyroid cancer Multiple endocrine neoplasia syndrome type 2 (MEN 2) Pregnancy Lactation Known allergy to semaglutide Animal studies suggest that GLP-1-RAs, including semaglutide, could lead to reduced embryo size and developmental anomalies
This larger sample size and longer duration provide more robust data for semaglutide, though the core finding remains consistent with other incretin studies
Sources / References The New England Journal of Medicine (NEJM) Phase 2 Trial (Primary Peer-Reviewed Study) Jastreboff AM, Kaplan LM, Fras JP, et al
Phase 2 trials used a structured titration protocol, typically starting at 0.5 mg once weekly and escalating to maintenance doses of up to 12 mg once weekly
Dr Sharwari Dabhade Dua, Endocrinologist, Dua Speciality Clinic, tells Health Shots: GLP/GIP analogs are now more popular, yet are indicated only in certain conditions
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