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Recent pharmaceutical interventions, especially GLP-1RAs, have advanced treatment for glycemic control and obesity

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This study indicate that the first site of metformin action is the gut, and through gut-portal vein-liver crosstalk, it may have a role in the control of HGP, integrating the sites and the mechanisms of metformin action

Existing GI issues that might worsen with GLP-1s

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These are the very systems influenced by GLP-1 pathways