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Plasma and tissue inflammation are exacerbated by higher levels of CCL11 and other cytokines in the CD8a + tm1mak mice (deficient in functional CD8 T-cells), leading to poor scar formation and the following cardiac rupture after myocardial infarction [39]
However, these symptoms are typically temporary
This is particularly relevant for patients who have not achieved adequate lipid control with statins alone
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GLP-1 medications can be effective while patients remain on them, but gastric sleeve often provides more durable long-term weight loss and does not depend on indefinite treatment
They're based on glycemic effects, not weight loss effects
