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This point will be further confirmed in our subsequent research

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Targeting GLP-1 receptor trafficking to improve agonist efficacy

According to FDA-approved prescribing information for semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), and tirzepatide (Mounjaro, Zepbound), food intake does not significantly affect the absorption or efficacy of these subcutaneous injections

This effect was observed in human umbilical vein endothelial cells treated with exendin-4 [67]

The mechanism involves glycine exerting a hyperpolarizing effect on macrophages and other immune cells, inhibiting calcium influx through voltage-sensitive channels and thereby dampening their inflammatory activity