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Hyperinsulinemia stimulates theca cells to produce testosterone, which is responsible for hirsutism in PCOS patients, and increased testosterone has an inhibitory effect on SHBG synthesis [Citation4]

Sleeve gastrectomy links the attenuation of diabetic kidney disease to the inhibition of renal tubular ferroptosis through down-regulating tgf-1/smad3 signaling pathway

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Proc Natl Acad Sci United States America (2015) 112(22):70616

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