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[9] Seek urgent medical attention (call 111, contact your GP urgently, or attend A&E) if you develop: Severe, persistent abdominal pain , particularly if it radiates to the back, as this may indicate pancreatitisa rare but serious adverse effect of GLP-1 agonists

Science 359 , 658662 (2018)

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Like other incretin-based therapies, retatrutide may slow gastric emptying, which could theoretically affect the absorption rate of orally administered medicines