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& Lamkanfi, M
Considering again that the myogenic stem cell activator HGF is found in an ECM-bound state 19,20,21,22,26 and undergoes nitration of tyrosine residues (Y198 and Y250) with aging 32,32,62 and muscle disuse (Kuwakdo et al., 2025), the present in vivo experiments provide a robust platform showing the potential for LASSS that could efficiently reduce or delay the nitration-dysfunction of ECM-bound HGF under peroxynitrite-generating conditions
Although the body produces its own L-carnitine, some people have lower levels due to genetics, dietary choices, or metabolic variations
Medications like metformin or acid blockers can also play a role
2: moderate and 3: severe