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Notably, based on the results from part 1 of the ESSENCE trial, on 15 August 2025, the FDA approved semaglutide 2.4 mg for the treatment of adults with MASH with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis)
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This allows for 48 hours of recovery between sessions, which is critical for preventing central nervous system (CNS) fatigue while the body adapts to medication
Nature 409 , 194198 (2001)
That had obvious implications for the treatment of diabetes
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