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The side effects that are known include nausea, vomiting, diarrhea, headache, dizziness, compaction in the gastrointestinal tract, and other GI-related symptoms like acid reflux, bloating, etc
TRIUMPH-4 (445 patients with knee osteoarthritis) reported results in December 2025, showing the 28.7% weight loss figure that made headlines worldwide (Lilly Press Release, Dec 2025)
Sources Wilding JPH, Batterham RL, Calanna S, et al
Most patients report reduced hunger and food cravings by day 7-10, even at starter doses
Semaglutide drugs themselves do not cause loose skin, but it can cause patients to lose weight faster than other forms of weight-loss methods, including bariatric surgery
Safety and Side Effects Like all therapeutic interventions, GLP-1 agonists come with their set of side effects
