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Of the surveyed propolis ointment group, 81.8% judged their treatment to be very effective compared to 60% of the placebo group finding the ointment hardly effective. 8 Utilizing propolis in conjunction with acyclovir has been shown to synergistically suppress HSV-1/-2 recurrence over acyclovir alone

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JAMA 315 , 26732682 (2016)

Topical applications, while they are beneficial for skin issues, they dont offer the systemic benefits of injections of pills