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Recognizing non-response allows pivoting to alternative approaches rather than continuing ineffective treatment

This creates a devastating feedback loop: mast cells release histamine, which causes systemic inflammation

Free Radic Biol Med 34:10781088 Chatterjee A (2013) Reduced glutathione: a radioprotector or a modulator of DNA-repair activity

The key to the process is a family of molecules called caspases, which act as shepherds of cell death and activate processes such as DNA degradation and the breakdown of organelles in the cell

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