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However, beneath the surface, another significant factor is at play which is oxidative stress
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Under unfolded protein stress conditions, GRP78 binds to unfolded or misfolded proteins and subsequently activates downstream ER stress sensors, including IRE1, PERK, and ATF6, to trigger a response to unfolded proteins (Yoboue et al., 2017) , (Wei et al., 2012)
The combination group showed significantly higher improvement scores than the dermaroller-only group at baseline and Week 3, with p-values indicating statistically significant differences
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