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doi: 10.3390/jcm10030441 20 McIlroyGDSuchackiKRoelofsAJYangWFuYBaiBet al

(2010a)

Collectively, these findings demonstrate that psychological trauma initiates a cascade of interconnected MGBA disruptions in PTSD, encompassing HPA axis dysregulation, microbial dysbiosis, compromised gut barrier integrity, chronic inflammation and neurotransmitter imbalances across serotonergic, dopaminergic, and GABAergic systems

But stress, toxins, poor diet and other lifestyle factors that increase its use will speed up depletion

SARM1 activation triggers axon degeneration locally via NAD destruction

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