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We tested it three more ways: Diagnosed by an eye-care specialist: 8.7 extra cases per 10,000) Repeated NAION diagnoses: 6.4 extra cases per 10,000) Specialist-diagnosed plus repeated: 5.9 extra casesWhy we think this is real, not a fluke

94 g Fmoc-Gly-2-CTC Resin (50 mmol) with a degree of substitution of 0.535 mmol/g was weighed and swelled for 30 min with DMF, followed by sequentially coupling according to the amino acid sequence of Semaglutide with 2-5 equivalents of amino acid feeds and condensing with DIC+A or B+A+C, until the resin was detected to be transparent with ninhydrin, wherein A was HOBt or HOAt

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In the reciprocal experiments, swapping the C-tail of either the rat or mouse receptor with that of the human GIPR improved arrestin recruitment to the receptor and internalization/desensitization (Gasbjerg et al., 2024)

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