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The researchers determined that initiating treatment with GLP-1 medications resulted in a higher 5-year risk of CKD and AKI, indicating healthcare professionals should take this data into consideration when choosing a medication for primary prevention of kidney disease in patients with type 2 diabetes
Nat Commun 2017
All physician-assigned discharge diagnoses are included, coded according to the International Classification of Diseases, Eight Edition (ICD-8) from 1977 until 1993 and according to ICD-10 from 1994 onwards
Although considerably smaller than the 34000Da peptide drugs, these small molecules are still around 700Da molecular weight further adding to computational modelling complexity
As discussed, GLP-1 decreases appetite and makes patients feel full longer, which leads to weight loss
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