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The combination of effects can lead to reduced calorie intake and, over time, significant weight loss

Also, while I am not a big calories believer, maybe my lunches are getting larger, eg, to pack in the pudding, and that has an effect too

From a mechanistic standpoint, these observations are mediated by GLP-1R in monocytes/macrophages and glomerular endothelial cells (Ye et al., 2019)

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REWIND Trial (Dulaglutide) Even in patients without a history of cardiovascular disease, dulaglutide reduced the risk of cardiovascular events by 12%

They are often life-long treatments needed to keep hormone levels stable