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Contraindications for Xigduo XR XIGDUO XR is contraindicated in patients with: Severe renal impairment (eGFR below 30 mL/min/1.73 m) or end-stage renal disease [see WARNINGS AND PRECAUTIONS ]

This phenomenon relates to the rapid change in glucose levels rather than a direct medication toxicity

Glucagon agonism in the treatment of metabolic diseases including type 2 diabetes mellitus and obesity

Acute pancreatitis and type 2 diabetes mellitus: glp-1 receptor agonist or idiopathic, a diagnostic dilemma, a case report with literature review

They have a direct anti-inflammatory effect of their own

Parting thoughts History offers a cautionary note