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However, the lack of targeted therapies in clinical practice contributes to a poor prognosis for patients with IIRI, which has a high mortality rate of 5069% [6]
Preventive therapies similar to those described for infusion reactions, as well as cooling pads or ice packs for symptomatic relief, may be helpful
While results from IV ALA studies are consistently positive, the picture is more mixed when it comes to oral-only supplementation: A four-year randomized trial found no significant improvement in a composite measure of nerve function with 600mg/day of oral ALA compared to placebo
PMID: 30261912
This is where supplementation steps in
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