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Heartburn and reflux symptoms appear to occur in a subset of patients, though exact prevalence rates vary depending on the trial population and reporting methods
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(More information) Elevated tryptophan breakdown in the kynurenine pathway and niacin deficiency have been reported in HIV-positive people
Free radicals can damage renal tubular cells and disrupt the function of sodium transporters, leading to sodium retention and increased blood volume, which further elevates blood pressure [82]
Based on the profile of participants enrolled in retatrutide trials to date, the drug appears most relevant to adults living with obesity (BMI 30 kg/m) or those who are overweight (BMI 27 kg/m) with weight-related health conditions such as type 2 diabetes, hypertension, dyslipidaemia, or obstructive sleep apnoea
