Notably, its incidence has risen sharply in recent years (110)
p62, also known as sequestosome 1, is a multifunctional junction protein involved in a number of cellular processes including autophagy, signaling and protein degradation (78)
However, when your glutathione reserves are too low, free radical damage can spiral out of control, leading to cell damage and the foundations for inflammatory health condition such as: Intestinal permeability (leaky gut) Chemical sensitivities Heavy metal sensitivities Autoimmune diseases and flares Inflammatory and immune disorders Glutathione depletion is also linked to a number of other disease states and groups: Aging Athletic overtraining Major injuries and trauma Patients with wasting diseases such as HIV and AIDS Lung cancer Gut-based diseases such as Crohns and ulcerative colitis Chronic fatigue syndrome Alcoholism and fatty liver disease Diabetes and low glucose tolerance Cancer In many of these cases, raising glutathione levels has shown therapeutic benefits
Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis
It works gently and is safe for caffeine-sensitive individuals
Additionally, GSH can react with the NO free radical to produce GSNO, which nitrosylates target proteins
