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Some large-scale data suggests a slightly increased risk of stones, often linked to dehydration from gastrointestinal side effects
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6 However, liraglutide has been the main drug in this class linked to skin reactions, with cases of exanthematous pustulosis in photo exposed areas, generalized erythematous plaques and nodules, and pruriginous macules at the injection site reported in the literature
A 2025 review provided updated assessment of its therapeutic mechanisms
The best injection site for semaglutide varies by individual anatomy and preference, with the abdomen, thigh, and upper arm being the standard options
