however we cannot establish causality based on these retrospective results and further prospective investigations are needed. In the second study, researchers focused on examining how GLP-1 use might impact the risk of developing osteoporosis, gout, or osteomalacia (bone softening) in people with type 2 diabetes and obesity
Side effects can include nausea, vomiting, diarrhea, constipation and, more rarely, issues like pancreatitis or gallbladder problems, so doctors often start patients on lower doses and monitor them closely
Nat Commun 15 , 6259 (2024)
Wegovy currently costs $1,349 per month and Mounjaro runs $1,060 per monththough both are falling fast: Novo Nordisk has already announced Wegovy will drop to $675/month starting January 2027, and government deals like TrumpRx and Medicare's GLP-1 Bridge are pushing many patients toward $50-$350/month
Positioned as a potential physiological regulator, LR3 IGF-I may govern [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts, demonstrating effective stimulation of glucose transport in bone-derived osteoblastic (PyMS) cells even at markedly lower concentrations than insulin
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