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In the first week, you can expect: Modest weight loss of 2-5 lbs as the medication begins to take effect Appetite suppression as one of the first noticeable effects Potential GI side effects like nausea as your body adjusts With semaglutide, the weight does not seem to come off rapidly or easily at first

Peng Y, Zhong G, Wang L, et al

This protocol reviews thyroid function and what happens when there is too much thyroid hormone activity in your body

Reprod Toxicol 2008;25:213-8

The same principle applies to obesity-specific GLP-1 medications, such as Wegovy , ZepBound , and Saxenda

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