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Am J Pathol (2012) 181:1693701
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HDAC6 inhibitors such as tubastatin A and the clinically approved ACY-1215 (rocilinostat) enhance aggresome formation and autophagic clearance, reducing tau and -synuclein aggregates in AD and PD models
Collectively, these findings highlight the role of carbohydrate metabolic pathways in sea urchins under nutrient-limited conditions, with evidence from other organisms indicating their involvement in regulating stress responses
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