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However, the most important caveat applies here: human pharmacokinetic data confirming systemic oral bioavailability does not exist in the peer-reviewed literature as of 2025
A strong comparison should connect mechanism, evidence strength, safety, access, and cost instead of only naming a winner
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If you have concerns about pain or side effects, our team is happy to discuss these with you before your treatment, ensuring you feel informed and comfortable every step of the way
The math changes when dependency is part of the deal
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