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The prospectively observed rate of cardiovascular malformations in pregnancies with exposure to bupropion in the first trimester from the international Pregnancy Registry was 1.3% (9 cardiovascular malformations/675 first-trimester maternal bupropion exposures), which is similar to the background rate of cardiovascular malformations (approximately 1%)
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Additionally, individual patient factorsincluding baseline gastric emptying rate, previous gastrointestinal conditions, concomitant medications, and genetic variations in drug metabolismcontribute to the considerable inter-patient variability observed in clinical practice
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