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The exact molecular mechanisms leading to WL and glycaemia improvements with tirzepatide are still under investigation, mainly because the role of GIP receptor activation with tirzepatide is unclear
To further interrogate the underlying dynamics of the Cagri-AMY 3 R complex, relative to rAmy-AMY 3 R complex, we performed molecular dynamics (MD) simulations of Cagri:AMY 3 R:G s and rAmy:AMY 3 R:G s (each system in triplicate, for a total of 6 s)
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