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This metabolic rewiring favors bacterial persistence but also leads to bioenergetic failure and excessive ROS accumulation in infected macrophages (Spooner and Yilmaz, 2011)

This subtle but important mechanism enables the solution to remain stable and safe for extended periods within a sealed vial when aseptic handling practices are followed

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The critical storage protocols, specifically refrigeration and the 28-day rule, only begin *after* you have opened the vial for the first time

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They are all ubiquitous except -butyrobetaine hydroxylase is absent from cardiac and skeletal muscle