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15% Patients lost an average of 15% of their body weight in ~1 year.* *In a 68-week double-blind trial studying once-weekly semaglutide injections (2.4 mg) in 1,961 patients without diabetes and with BMI 30, or BMI 27 with a weight-related condition, the average weight loss was 15%, when paired with diet and exercise changes
doi: 10.1002/mnfr.202000149 51 HanninenA.ToivonenR.PoystiS.BelzerC.PlovierH.OuwerkerkJ
Nutriologa Mdica
Those numbers come from SURMOUNT-5, published in the New England Journal of Medicine
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Verdict at a Glance Pemvidutide and survodutide are both GLP-1/glucagon dual agonists being developed for obesity and MASH, but survodutide is further ahead in clinical development with more advanced Phase 3 programs, higher-tier regulatory designations (Breakthrough Therapy vs Fast Track), and greater weight loss in Phase 2 (18.7% vs 15.6%)
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