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Euthanasia criteria were set for experimental animals with significant health decline or unmanageable distress and this included persistent weight loss exceeding 20% of the initial body weight, behavioral changes such as severe lethargy, unresponsiveness, excessive grooming leading to self-injury, or vocalization, signal distress warranting euthanasia

Timofeeva , Minina VI, Torgunakova AV, Soboleva , itov R, Zakharova Y, et al

Duranton C, Huber SM, Lang F

Both have clinical utility, but not for the same indication

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