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PMID: Summary Keywords GLP-1 receptor (GLP-1R), metabolic dysfunction, Mitochondria-ER Contact Sites (MERCS), signalosomes, GLP1 receptor agonist (GLP1-RAs) Citation Cruz P, Puebla-Huerta A, Troncoso MF, Silva-Pavez E, Hidalgo-Fadic Y and Ahumada-Castro U (2026) GLP-1 receptor and Mitochondria-ER Contact Sites: an emerging mechanism of metabolic regulation

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Another shot we offer at LIVation is a GLP-1 agonist, but it is also a GIP agonist, meaning it works on both your GLP-1 receptor and gastric inhibitory polypeptide receptor

The next table organizes these benefits by organ system, showing how widespread their impact is

Sorolla MA, Reverter-Branchat G, Tamarit J, Ferrer I, Ros J, Cabiscol E

The STEP trials showed that semaglutide produced average weight loss of 10-15% of body weight, which directly correlates with improved insulin sensitivity and reduced diabetes risk