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AOD-9604 should be avoided or used only under close medical supervision in certain populations

Of the 32 GLP-1 RA prescriptions Patient Sim obtained, the median supply was 1.0 months (IQR, 1.0-1.6) at a median price of $230.00 per month (IQR, $163.80-$294.70), with 30 sourced from 20 unique compounding pharmacies

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PROTAC degraders offer several advantages over traditional small molecule inhibitors, including its intrinsic event-driven pharmacology and nonlinear pharmacodynamics, improved safety profiles, and reduced risk of drug resistance

Alpha-synuclein, the primary component of Lewy bodies, is prone to oxidative modifications, which can promote its aggregation and toxicity