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The mechanism story is broad, but most of it is built on cell and animal models

Oct4 is required for primordial germ cell survival

Abbreviations MTHFR: Methylenetetrahydrofolate reductase GSTO-1: Glutathione S-transferase omega-1 ROS: Reactive oxygen species DNA: Deoxyribonucleic acid HHcy: Hyperhomocysteinemia Hcy: Homocysteine TOAST: Trial of ORG 10172 in Acute Stroke Treatment PCR: Polymerase chain reaction HWE: Hardy-Weinberg equilibrium

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