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Bohr S, Patel SJ, Sarin D, Irimia D, Yarmush ML, Berthiaume F (2013) Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model

2020 Oct;46(4):1347-1358

The rationale for titrating upward over time, rather than starting at the target dose, mirrors the approach taken with other metabolic peptides: the goal is to identify the minimum effective dose for each individual while monitoring for tolerability

Glutathione is thought to brighten skin in two linked ways: by inhibiting tyrosinase (the key enzyme in pigment production) and by shifting melanin synthesis from darker eumelanin toward lighter pheomelanin

She adds that starting with a lower dose of 2 mg/week instead of 4 mg/week may help mitigate adverse effects

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