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The precise mechanisms by which amlodipine relieves angina have not been fully delineated, but are thought to include the following: Exertional Angina In patients with exertional angina, amlodipine besylate reduces the total peripheral resistance (afterload) against which the heart works and reduces the rate pressure product, and thus myocardial oxygen demand, at any given level of exercise
John: Is this going to be also transdermal or how are we going to take that
REFERENCE: Goswami A, Rosenberg I
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Recovery from the degenerative phenotypes and reduced oxidative stress therefore, contributed to better survivability of the Sp- park 13 flies, which was comparable to Oregon R + (Fig