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LPS triggers systemic inflammation through the TLR4-NF-B pathway, promoting the release of pro-inflammatory cytokines and directly exacerbating myocardial apoptosis, fibrosis, and microvascular obstruction, thus forming an injury-translocation-inflammation-worsened injury cascade (Snelson et al., 2025)

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10.2196/ijmr.3160 103 RaimundoN.VanharantaS.AaltonenL

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