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Due to the limit of available articles at the time of search, the initial search was quite broad with a very narrow final evidence base which mainly resulted in case reports or case series, narrative scoping reviews, or small retrospective cohorts
However, it carries only a fifth of the weight THNR assigns to life sciences and services
The 2021 SCALE Obesity and Prediabetes trial (N=3,731) showed that liraglutide 3.0 mg combined with structured lifestyle intervention produced 8.0% mean weight loss vs
The mechanism is confirmed as FXR agonists reverse these effects, highlighting the gut-liver axiss critical role (9)
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Zubeldia, J.M., et al
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