PLoS One 8 : e61965
As fat stores shrink, the tops of your feet may look less full or even saggy
N Engl J Med 375:311322 Ahrn B, Masmiquel L, Kumar H, Sargin M, Karsbl JD, Jacobsen SH, Chow F (2017) Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2): a 56-week, double-blind, phase 3a, randomised trial
SERT was administered at 5 mg/kg[38], while DEX was administered at 4 mg/kg[39-41]
Excess fat also can cause vascular damage and common pathophysiologic processes, such as oxidative stress, inflammation, and leptin resistance
Myocardial inflammatory infiltration in diabetics suggests chronic inflammation and consequent cardiac marker alterations, typically mediated by increased NF-B nuclear activity, inducing elevated inflammatory mediators like ICAM-1 and VCAM-1 (Shakour et al., 2024)