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Perspectivas futuras Hoy en da, el arsenal farmacolgico disponible contempla el abordaje de nuevas patologas, como la enfermedad arterial perifrica o las afecciones neurodegenerativas, lo que refrenda el papel de las enfermedades metablicas en la fisiopatologa de diversos trastornos con un profundo impacto en la calidad y la expectativa de vida de la poblacin60

Hamid Djalilian, an ear specialist and tinnitus specialist at the UC Irvine School of Medicine

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P-26 Clinical investigation of hereditary angioedema linked to coagulation factor XII mutations in a Southern Spanish cohort Teresa De Aramburu Mera, Krasimira Baynova, Jos Ral Garca Lozano, Jose Manuel Lucena Soto, Stefan Cimbollek Spanish National Center for Angioedema Allergy Department Virgen del Roco University Hospital, Seville, Spain Allergy, Asthma & Clinical Immunology 2025, 21(Suppl 2) :P-26 Introduction: Numerous alterations genetic in the Factor XII gene associated with HAE-FXII have been documented since its genetic characterization in 2006

Upon exposure to H 2 O 2 , the free iron in lysosomes increases the production of ROS, which can then be released through an unstable lysosomal membrane to trigger the activation of cell death pathways 12

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