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Based on a previous work, 30 mg/kg was considered the dose sufficient to achieve a C max comparable to the L-carnitine concentration used in vitro (1 mM) 41
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Cases were divided into two groups: 1) Group A patients received metformin, DPP-4 inhibitor + sulfonylurea prior to the index date, and 2) Group B patients were prescribed insulin therapy + other oral agents prior to the index date
Collectively, these data demonstrate the diversity and flexibility of ECL1 among class B GPCRs
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