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Semaglutide for weight loss is not designed to be taken long term

doi: 10.1016/j.foodres.2022.112226 112 KumarJRaniKDattC

Several compounding pharmacies and advocacy groups challenged the FDA decision in court

Tirzepatide-based evidence from the SURPASS (Researching Tirzepatide in Patients with Type 2 Diabetes for Glycemic Control and Weight Management) trials (SURPASS-1 NCT03954834 and SURPASS-5 NCT04039503) demonstrated dose-dependent, significant weight loss over 40 weeks compared with placebo, along with reductions in BMI and waist circumference [62, 63]

Alternative dosing strategies for tirzepatide may reduce dose-related side effects

The decision to initiate pharmacotherapy should involve shared decision-making, considering individual patient values, preferences, treatment goals, and cost considerations, as these medications can be expensive and may face insurance coverage limitations