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Headaches, nausea, diarrhea, fatigue, and tingling in extremities are very rare

14.3.2 Semaglutide Semaglutide is a GLP-1 receptor agonist that is dosed once a week subcutaneously based on its extended half-life

DOI: 10.3390/ijms222313068

More serious concerns have been reported

Antioxid Redox Signal 28:16261651 Diaz-Hung ML, Yglesias-Rivera A, Hernandez-Zimbron LF, Orozco-Suarez S, Ruiz-Fuentes JL, Diaz-Garcia A, Leon-Martinez R, Blanco-Lezcano L, Pavon-Fuentes N, Lorigados-Pedre L (2016) Transient glutathione depletion in the substantia nigra compacta is associated with neuroinflammation in rats

The combination of afamelanotide implant plus NB-UVB achieved 48.6% repigmentation at day 168, compared to 33.3% with NB-UVB monotherapy a statistically significant and clinically meaningful difference (Lim et al., 2015)