Research on transdermal drug delivery shows that even with enhancement technologies, only certain types of molecules can achieve meaningful absorption rates
The experience with tirzepatide (Mounjaro/Zepbound) is instructive
Key Ingredients: Glycine, Proline, Lysine, Niacinamide, Centalla Asiatica, Emblica Officinalis, Vitamin C and Ocimum Sanctum
Bibcode:2014TPS....19..789A
For patients who have difficulty absorbing B12 through the digestive tractsuch as those with pernicious anemia, gastrointestinal disorders (like Crohns disease or celiac disease), a history of gastric bypass surgery, or those with severe B12 deficiencyour providers often recommend intramuscular B12 injections
As of mid-2026, neither cagrilintide nor retatrutide is FDA- or EMA-approved for any indication, and no legitimate prescription product exists for either