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Exendin-4 (Ex-4), another GLP-1RA that is homologous to commercially available exenatide, ameliorated IR in primary neurons through insulin receptor substrate-1 (IRS-1), AKT, and glycogen synthase kinase-3 (GSK-3) pathways

Sold under the brand name Egrifta, Tesamorelin was approved by the FDA in November 2010 for reducing excess abdominal fat in HIV-infected patients with lipodystrophy

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However, besides several case reports and observational studies, no large clinical trial specifically linking GLP-1 RAs to either increased risk or protection from NAION has been published

In a smaller cohort of patients with more severe CD phenotypes, including 17% with perianal involvement and 24% with penetrating or fistulizing disease, numerical reductions across outcomes were observed in the GLP-1RA group, but these differences did not reach statistical significance (104)

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