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Bone Density Declines Linked to Weight Loss Magnitude A retrospective review presented at the 2025 Endocrine Society meeting examined 255 patients (92% female, 63% white, average age 689 years) who had at least 6 months of semaglutide or tirzepatide use and 2 bone mineral density (BMD) scans on the same machine

Start with lower doses to assess tolerance

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Concurrently, the expression of HMG-CoA synthasea pivotal ketogenic enzymemay undergo analogous modulation, while HMG-CoA reductase activity (its downstream counterpart) is suppressed, thereby reducing fatty acid conversion to cholesterol