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Microglia are P2RY12 + CD11b + CD45 mid

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Key properties: Stimulates GH release from the pituitary (not the hypothalamus) Does not significantly raise cortisol or prolactin Short half-life (~2 hours) produces a sharp, pulsatile GH release Does not block somatostatin (the hormone that inhibits GH release) Selective for GH minimal effect on other hormones The selectivity is what makes ipamorelin the preferred GHRP for most protocols

However, it is worth noting that GLP-1-based therapies can sometimes reduce lean muscle mass alongside fat, particularly without adequate protein intake and resistance exercise so muscle gain should not be assumed without objective body composition assessment

The combination addresses multiple aspects of a metabolic-neurological clinical picture without competing for receptor or pathway