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Certainly, an increase in IGF-1 action is associated with greater risk for neoplastic disease, a link further supported by this study and others targeting IGF-1Rs, but IGF-1 has been paradoxically associated with protection against osteoporosis, type 2 diabetes, cerebrovascular and cognitive decline in pre-clinical studies, as well as in some human epidemiologic studies 12

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MTII activates melanocortin receptors (MC1R through MC5R) with substantially higher potency than endogenous -MSH, making it a pharmacological research tool for studying the melanocortin system