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Clinicians must take into account mechanisms of action, level of HbA1c reduction, impact on fasting plasma glucose and/or post-prandial glucose levels, safety and tolerability, effects on weight, route of administration, and finally, cost
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Kosower NS et al
Melatonin is mainly produced during the dark phase, and the maximal plasma concentration of this serotonin-derived hormone usually occurs 45 h after darkness onset 11
Depending on your specific goals, treatment plans may involve multiple infusions over several months
Future research will help us better understand whether the additional weight loss seen with tirzepatide translates into superior long-term health benefits compared with other GLP-1 therapies. While tirzepatide may lead to greater weight loss, a semaglutide medication may be more suitable for some people
